WebSep 1, 2024 · The idea that lysosomal biogenesis induced by the accumulation of hydrophobic weak base drugs at nanomolar concentrations increases their sequestration and thus enhances the cellular resistance to these drugs, is a very attractive explanation for the putative mechanism of resistance [20]. In the introduction, we wrote that lysosomal ... WebFeb 1, 2024 · Cracking outer membrane biogenesis. Gram-negative bacteria contain an outer membrane that lies on the external face of the peptidoglycan sacculus. The outer membrane consists of lipopolysaccharide, phospholipids, lipoproteins, and integral beta-barrel proteins. Components of the outer membrane are made in the cytoplasm and …
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